Sunday, October 4, 2009

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Must Read
F1000 Factor 6.0

New Finding
Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial.
Verdecchia P, Staessen JA, …, Reboldi G, Cardio-Sis investigators
Lancet 2009 Aug 15 374(9689):525-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carmine Zoccali
Evaluated 2 Oct 2009

Recommended
F1000 Factor 3.0

New Finding
Cost Effectiveness and Screening Interval of Lipid Screening in Hodgkin's Lymphoma Survivors.
Chen AB, Punglia RS, …, Mauch PM, Ng AK
J Clin Oncol 2009 Sep 14 [abstract on PubMed] [related articles] [full text]
Selected by | Saro Armenian and Smita Bhatia
Evaluated 2 Oct 2009

Recommended
F1000 Factor 3.0

New Finding
Complementary Prognostic Values of Stress Myocardial Perfusion and Late Gadolinium Enhancement Imaging by Cardiac Magnetic Resonance in Patients With Known or Suspected Coronary Artery Disease.
Steel K, Broderick R, …, Brown KA, Kwong RY
Circulation 2009 Sep 21 [abstract on PubMed] [related articles] [full text]
Selected by | Christopher Kramer
Evaluated 1 Oct 2009

Must Read
F1000 Factor 6.0

Confirmation
Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I.
Kruse M, Schulze-Bahr E, …, Brink P, Pongs O
J Clin Invest 2009 Sep 119(9):2737-44 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Nathalie Neyroud and Pascale Guicheney
Evaluated 1 Oct 2009


Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist.
Zhang Y, Deb DK, …, Arbeeny C, Li YC
Am J Physiol Renal Physiol 2009 Sep 297(3):F791-801 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Roberto Zatz
Evaluated 29 Sep 2009

Must Read
F1000 Factor 6.0

Hypothesis
Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect.
Hiller DB, Gregorio GD, …, Feinstein DL, Weinberg GL
Anesthesiology 2009 Sep 111(3):498-505 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tighe and Andre Boezaart
Evaluated 29 Sep 2009

Must Read
F1000 Factor 6.0

Confirmation
Usefulness of the valvuloarterial impedance to predict adverse outcome in asymptomatic aortic stenosis.
Hachicha Z, Dumesnil JG, Pibarot P
J Am Coll Cardiol 2009 Sep 8 54(11):1003-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Paraskos
Evaluated 28 Sep 2009

Recommended
F1000 Factor 3.0

Confirmation
Combining estimates of interest in prognostic modelling studies after multiple imputation: current practice and guidelines.
Marshall A, Altman DG, Holder RL, Royston P
BMC Med Res Methodol 2009 9:57 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yvonne Vergouwe
Evaluated 28 Sep 2009

Recommended
F1000 Factor 3.0

Confirmation
Secondary intervention after endovascular abdominal aortic aneurysm repair.
Conrad MF, Adams AB, …, LaMuraglia GM, Cambria RP
Ann Surg 2009 Sep 250(3):383-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Norman Hertzer
Evaluated 28 Sep 2009

Exceptional
F1000 Factor 8.2
Articles that inform your practice or change your way of thinking
Changes
Clinical Practice

Confirmation
Hypothesis
Fluvastatin and perioperative events in patients undergoing vascular surgery.
Schouten O, Boersma E, …, Poldermans D, Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group
N Engl J Med 2009 Sep 3 361(10):980-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruce Biccard / Seemant Chaturvedi / Jan Larmann and Gregor Theilmeier
First evaluation 25 Sep 2009 | Latest evaluation 1 Oct 2009

Tuesday, September 29, 2009

Swine flu (H1N1)

Fever Scan M3000 Series: System for SARS / Avian Flu / Bird Flu & Swine Flu(H1N1) Detection

The Cantronic Systems Inc. Fever Scan M3000S System is designed for mass screening of public areas; using IR technology, it finds individuals with elevated body temperatures. As a group of people walk past the camera, a thermal image is displayed. Body temperatures above a predefined value can be visually identified and then further assessed by medical personnel. Swine Flu, Swine Flu, Swine Flu, Bird Flu, SARS, SARS

The FeverScan M3000S is a dynamic real time thermal imaging camera system that is capable of evaluating hundreds of people per minute, so pedestrian flow is not restricted. The Fever Scan M3000 is ideal for mass screening for SARS (Severe Acute Respiratory Syndrome), Avian Flu, Bird Flu and Swine Flu(H1N1) in areas like airports, railway or subway stations, seaports, and any other public facilities.

FeverScan M3000D is a system improvement upon our popular M3000/M3000S system. It adds a visual sensor to the thermal, creating a dual sensor camera head. The visual/thermal comparison allows for easier/faster screening—the operator can screen for fever and identify at the same time.

FeverScan 3000S SARS / Avian Flu / Swine Flu(H1N1) Camera Data Sheet

FeverScan 3000D SARS / Avian Flu / Swine Flu(H1N1) Dual Vision Camera Data Sheet

Main Features:

FeverScan 3000 SARS Flu Camera FeverScan 3000 SARS Flu Camera
  • Pre-definable value for abnormal body temperatures
  • B&W image with red hot spots to indicate high temperatures
  • Adjustable temperature range on display palette
  • Spot check with mouse cursor for actual temperature readings
  • Alarm settings
  • Log file to record data

The System comes complete with thermal camera, software with frame grabber, and computer terminal.

Camera Specifications

Similar Products

IR860M Medical Thermography
Fever Scan M3000
Lens: 50mm
Focal Plane Array Micro-bolometer (Amorphous silicon or vanadium oxide)
Spectral range 8-14 µm
Number of Pixels 320x240
NETD 0.08° C @ 30° C
Image Frequency 7.5Hz (NTSC) or 8.3Hz (PAL)*

Software User Interface:

Data Display 640x480 on screen/processing
Visual Alarm User definable temperature scale and alarm trigger point
Alarm Function Ignore Mode or Save Alarm Mode (saves image to hard drive and log file for easy retrieval/review)

Optional:

VGA Monitor, Printer, Tripod.

Lung cancer

Radiofrequency Ablation (RFA)

This is a method for treating some tumors using the concept of thermal ablation. We currently offer RFA of osteoid osteomas, other painful bone metastases, lung cancers and liver cancers.

Sunday, September 27, 2009

pharmaceutical news

Receive free subspecialty "5-minute updates" via email Comparing Generic and Innovator Drugs: A Review of 12 Years of Bioequivalence Data from the United States Food and Drug Administration
Annals of Pharmacotherapy, 09/25/09
Sponsor
Anti-Cancer Agent Xeloda and Avastin Obtained Approval for Additional Indication of Colorectal Cancer
Chugai Pharmaceutical Co., 09/25/09 Free full text Sandoz completes acquisition of EBEWE Pharma, improving global patient access to affordable injectable cancer medicines
Novartis, 09/25/09 Free full text New Data Support Safety of Aquacel Ag Dressing
Wounds, 09/25/09 Results from Abbotts PROSPECT Study Provide New Insight into Role of Vulnerable Plaque in Coronary Artery Disease
Abbott, 09/25/09 Cephalon Announces that FDA Grants Priority Review of its Supplemental New Drug Application for NUVIGIL as a Treatment for Excessive Sleepiness Associated with Jet Lag Disorder
Cephalon, 09/25/09 Free full text Docs Use RHIO to Access Images
HealthDataManagement, 09/25/09 Vectibix(R) in Combination With Chemotherapy Significantly Improves Progression-Free Survival in First-Line Metastatic Colorectal Cancer
Amgen, 09/25/09 Free full text Herceptin provides impressive survival benefit for patients with high levels of HER2 in their stomach cancer
Roche, 09/25/09 Free full text Results Of Adagio Study With Azilect In Parkinson's Disease Published In New England Journal Of Medicine
Teva Pharmaceutical Industries, 09/25/09 Free full text Ticagrelor reduced cardiovascular deaths and heart attacks in ACS patients undergoing heart procedures: New data from PLATO trial
AstraZeneca, 09/25/09 Free full text Merck Statement on HIV Vaccine Trial
Merck & Co., 09/25/09 Free full text Teva Provides Update On Generic Evista Litigation
Teva Pharmaceutical Industries, 09/25/09 Free full text BTG plc: Campath Meets Primary Endpoint in Phase III Combination Therapy Trial for Chronic Lymphocytic Leukemia
BTG, 09/25/09 Free full text Sanofi Pasteur Commends Results of First HIV Vaccine Study to Show Some Effectiveness in Preventing HIV
Sanofi-aventis, 09/25/09 Free full text Continuous improvements in animal welfare within Roche Research
Roche, 09/25/09 Free full text OPAXIO Phase II Trial in Esophageal Cancer to be Presented in Proffered Session at the International Society of Gastrointestinal Oncology Annual Meeting
Cell Therapeutics, 09/25/09 Free full text Genzyme’s Campath Meets Primary Endpoint in Phase 3 Combination Therapy Trial for Chronic Lymphocytic Leukemia
Genzyme, 09/25/09 Free full text Farletuzumab Data Presented on Phase II Clinical Trial in First-Relapsed Ovarian Cancer Subjects
Morphotek, 09/25/09 Free full text Dendreon Reports PROVENGE Regulatory and Commercialization Progress and Future Pipeline Plans at Analyst Event
Dendreon Coproration, 09/25/09 Free full text

swimming in ice cold water

Swimming in ice cold water
Irish Journal of Medical Science, 09/25/09
Sponsor
Incidence and Patterns of Adverse Event Onset During the First 60 Days After Ventricular Assist Device Implantation
Annals of Thoracic Surgery, 09/25/09 Emergency Medical System response to out-of-hospital cardiac arrest in Milan, Italy
European Journal of Emergency Medicine, 09/25/09 Cost-effectiveness of genotype-guided warfarin therapy for anticoagulation in elderly patients with atrial fibrillation
The American Journal of Geriatric Pharmacotherapy, 09/25/09 Increased Susceptibility of Aged Hearts to Ventricular Fibrillation During Oxidative Stress
Heart And Circulatory Physiology, 09/25/09
Exclusive Author Commentary
Esophagus imaging for catheter ablation of atrial fibrillation: comparison of two methods with showing of esophageal movement
Journal of Interventional Cardiac Electrophysiology, 09/25/09 The variable functional effects of the pacing site in normal and scarred ventricles
Journal of Nuclear Cardiology, 09/25/09 Echo Doppler guidance for atrial fibrillation ablation: recognition of primary electropathy
Journal of Interventional Cardiac Electrophysiology, 09/25/09

Prior Articles


Association of the Parameters Derived From the Relation Between RR Intervals and Left Ventricle Performance with a History of Heart Failure in Patients With Atrial Fibrillation
The American Journal of Cardiology, 09/24/09 Frequencies and Types of Arrhythmias in Patients With Systemic Light-Chain Amyloidosis With Cardiac Involvement Undergoing Stem Cell Transplantation on Telemetry Monitoring
The American Journal of Cardiology, 09/24/09 Rationale for Continuous Chest Compression Cardiopulmonary Resuscitation
Heart, 09/24/09 Role of echocardiography in selection of patients for biventricular pacing therapy
Current Cardiology Reports, 09/24/09 Selective Site Right Ventricular Pacing
Heart, 09/24/09 The influence of postoperative mitral valve function on the late recurrence of atrial fibrillation after the maze procedure combined with mitral valvuloplasty
The Journal of Thoracic and Cardiovascular Surgery, 09/24/09 Bisphosphonate and atrial fibrillation: Bayesian meta-analyses of randomized controlled trials and observational studies
BMC Musculoskeletal Disorders, 09/24/09 Free full text Out of Hospital Cardiac Arrest in South Asian and White populations in London: database evaluation of characteristics and outcome
Heart, 09/24/09 Ablation strategies for atrial fibrillation
Expert Review of Cardiovascular Therapy, 09/24/09 Update on primary prevention implantable cardioverter-defibrillator therapy
Current Cardiology Reports, 09/23/09 Genetic testing in the management of inherited arrhythmia syndromes
Current Cardiology Reports, 09/23/09

Thursday, August 27, 2009

lung anatomy


Lung
—Anatomy

Breathing is important because your body needs the oxygen in the air you breathe to create the energy that keeps you alive.

When fresh air is breathed in through the nose and mouth, it is pulled through the windpipe or trachea and into the lungs. (You have two lungs, with the right lung being slightly larger than the left lung.) From the windpipe, the air moves through two large passageways, called the bronchi. A complex system of much smaller tubes or bronchioles branch out from your bronchi to carry oxygen to the "working parts" of the lungs — the millions of air sacs or alveoli. These small sacs (like tiny folded balloons) have very thin walls that are full of blood vessels. The walls are so thin that the oxygen in the air can pass through them to enter your bloodstream and travel to cells in all parts of your body.

So when you breathe in, you are inhaling oxygen which is the “fuel” to make your body cells work. And when you breathe out, you are exhaling the byproduct of your body cells’ work – a gas called carbon dioxide, which is often called "used" air. Carbon dioxide, is exhaled with every breath you blown out of your lungs.

Animation of lungsD

Monday, August 24, 2009

anatomy of the heart


1. Right Coronary
2. Left Anterior Descending
3. Left Circumflex
4. Superior Vena Cava
5. Inferior Vena Cava
6. Aorta
7. Pulmonary Artery
8. Pulmonary Vein



9. Right Atrium
10. Right Ventricle
11. Left Atrium
12. Left Ventricle
13. Papillary Muscles
14. Chordae Tendineae
15. Tricuspid Valve
16. Mitral Valve
17. Pulmonary Valve
Aortic Valve (Not pictured)

Coronary Arteries

Because the heart is composed primarily of cardiac muscle tissue that continuously contracts and relaxes, it must have a constant supply of oxygen and nutrients. The coronary arteries are the network of blood vessels that carry oxygen- and nutrient-rich blood to the cardiac muscle tissue.

The blood leaving the left ventricle exits through the aorta, the body’s main artery. Two coronary arteries, referred to as the "left" and "right" coronary arteries, emerge from the beginning of the aorta, near the top of the heart.

The initial segment of the left coronary artery is called the left main coronary. This blood vessel is approximately the width of a soda straw and is less than an inch long. It branches into two slightly smaller arteries: the left anterior descending coronary artery and the left circumflex coronary artery. The left anterior descending coronary artery is embedded in the surface of the front side of the heart. The left circumflex coronary artery circles around the left side of the heart and is embedded in the surface of the back of the heart.

Just like branches on a tree, the coronary arteries branch into progressively smaller vessels. The larger vessels travel along the surface of the heart; however, the smaller branches penetrate the heart muscle. The smallest branches, called capillaries, are so narrow that the red blood cells must travel in single file. In the capillaries, the red blood cells provide oxygen and nutrients to the cardiac muscle tissue and bond with carbon dioxide and other metabolic waste products, taking them away from the heart for disposal through the lungs, kidneys and liver.

When cholesterol plaque accumulates to the point of blocking the flow of blood through a coronary artery, the cardiac muscle tissue fed by the coronary artery beyond the point of the blockage is deprived of oxygen and nutrients. This area of cardiac muscle tissue ceases to function properly. The condition when a coronary artery becomes blocked causing damage to the cardiac muscle tissue it serves is called a myocardial infarction or heart attack.
Superior Vena Cava

The superior vena cava is one of the two main veins bringing de-oxygenated blood from the body to the heart. Veins from the head and upper body feed into the superior vena cava, which empties into the right atrium of the heart.
Inferior Vena Cava

The inferior vena cava is one of the two main veins bringing de-oxygenated blood from the body to the heart. Veins from the legs and lower torso feed into the inferior vena cava, which empties into the right atrium of the heart.
Aorta

The aorta is the largest single blood vessel in the body. It is approximately the diameter of your thumb. This vessel carries oxygen-rich blood from the left ventricle to the various parts of the body.
Pulmonary Artery

The pulmonary artery is the vessel transporting de-oxygenated blood from the right ventricle to the lungs. A common misconception is that all arteries carry oxygen-rich blood. It is more appropriate to classify arteries as vessels carrying blood away from the heart.
Pulmonary Vein

The pulmonary vein is the vessel transporting oxygen-rich blood from the lungs to the left atrium. A common misconception is that all veins carry de-oxygenated blood. It is more appropriate to classify veins as vessels carrying blood to the heart.
Right Atrium

The right atrium receives de-oxygenated blood from the body through the superior vena cava (head and upper body) and inferior vena cava (legs and lower torso). The sinoatrial node sends an impulse that causes the cardiac muscle tissue of the atrium to contract in a coordinated, wave-like manner. The tricuspid valve, which separates the right atrium from the right ventricle, opens to allow the de-oxygenated blood collected in the right atrium to flow into the right ventricle.
Right Ventricle

The right ventricle receives de-oxygenated blood as the right atrium contracts. The pulmonary valve leading into the pulmonary artery is closed, allowing the ventricle to fill with blood. Once the ventricles are full, they contract. As the right ventricle contracts, the tricuspid valve closes and the pulmonary valve opens. The closure of the tricuspid valve prevents blood from backing into the right atrium and the opening of the pulmonary valve allows the blood to flow into the pulmonary artery toward the lungs.
Left Atrium

The left atrium receives oxygenated blood from the lungs through the pulmonary vein. As the contraction triggered by the sinoatrial node progresses through the atria, the blood passes through the mitral valve into the left ventricle.
Left Ventricle

The left ventricle receives oxygenated blood as the left atrium contracts. The blood passes through the mitral valve into the left ventricle. The aortic valve leading into the aorta is closed, allowing the ventricle to fill with blood. Once the ventricles are full, they contract. As the left ventricle contracts, the mitral valve closes and the aortic valve opens. The closure of the mitral valve prevents blood from backing into the left atrium and the opening of the aortic valve allows the blood to flow into the aorta and flow throughout the body.
Papillary Muscles

The papillary muscles attach to the lower portion of the interior wall of the ventricles. They connect to the chordae tendineae, which attach to the tricuspid valve in the right ventricle and the mitral valve in the left ventricle. The contraction of the papillary muscles opens these valves. When the papillary muscles relax, the valves close.
Chordae Tendineae

The chordae tendineae are tendons linking the papillary muscles to the tricuspid valve in the right ventricle and the mitral valve in the left ventricle. As the papillary muscles contract and relax, the chordae tendineae transmit the resulting increase and decrease in tension to the respective valves, causing them to open and close. The chordae tendineae are string-like in appearance and are sometimes referred to as "heart strings."
Tricuspid Valve

The tricuspid valve separates the right atrium from the right ventricle. It opens to allow the de-oxygenated blood collected in the right atrium to flow into the right ventricle. It closes as the right ventricle contracts, preventing blood from returning to the right atrium; thereby, forcing it to exit through the pulmonary valve into the pulmonary artery.
Mitral Value

The mitral valve separates the left atrium from the left ventricle. It opens to allow the oxygenated blood collected in the left atrium to flow into the left ventricle. It closes as the left ventricle contracts, preventing blood from returning to the left atrium; thereby, forcing it to exit through the aortic valve into the aorta.
Pulmonary Valve

The pulmonary valve separates the right ventricle from the pulmonary artery. As the ventricles contract, it opens to allow the de-oxygenated blood collected in the right ventricle to flow to the lungs. It closes as the ventricles relax, preventing blood from returning to the heart.
Aortic Valve

The aortic valve separates the left ventricle from the aorta. As the ventricles contract, it opens to allow the oxygenated blood collected in the left ventricle to flow throughout the body. It closes as the ventricles relax, preventing blood from returning to the heart.